Our research focuses on combining rational design and synthetic chemistry to probe challenges in biology and medicine. Our projects involve modern (bio)organic syntheses, such as solid-phase synthesis, bioconjugation, combinatorial chemistry, and total chemical protein synthesis. Our research projects include the following:
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Development of new methods for the synthesis of therapeutic peptides and proteins
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Design and synthesis of bioactive macromolecules to inhibit oncogene expression
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Understanding the impact of posttranslational modifications on oncogene expression
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Building artificial nucleic acid binding proteins
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Refining the delivery of bioactive macromolecules