Physical Chemistry Seminar: Innovations in Continuous Physiological Monitoring: Advancing Biosensors with On-Demand Reversibility and Scalable Arrays

Zoom: https://tau-ac-il.zoom.us/j/87820055721?pwd=kewAaVRPgfvQXtUuQD41aWPtcLcecQ.1

Abstract:

Providing continuous, real-time insights into an individual's clinically relevant biomarkers has immense promise in revolutionizing healthcare, as it enables early detection of deviations from normal bodily functions, facilitating timely intervention and personalized treatment plans. Recent advancements in materials engineering and biosensor technology have paved the way for significant progress in the field of in-vivo physiological monitoring. However, as we navigate through this developing field, there is a pressing need to tackle critical challenges, including the enhancement of stability, sensitivity, and reversibility. These requirements are essential for unlocking the potential of these innovative technologies in widespread applications.

In this seminar, I will delve into the various sensing requirements and technological approaches needed to achieve reliable and accurate monitoring of complex physiological signals within living organisms. Discussions will center on sensor design and performance. I will present the development of electrochemical biosensors based on molecularly imprinted polymer (MIP) technology, focusing on overcoming the critical aspects of the sensitivity-reversibility tradeoff. This breakthrough has practical implications for these biosensors in the realm of neurochemistry. I will demonstrate an ultra-sensitive MIP-based melatonin microwire sensor designed to track circadian rhythms and aid in the amelioration of jet lag among warfighters. Next, I will present a highly scalable microwire array engineered to facilitate the precise and real-time monitoring of dopamine release with unparalleled spatiotemporal resolution.

My future research vision is to advance the development of next-generation biosensing technologies that integrate multifaceted approaches to enhance the precision and reliability of continuous physiological monitoring. By leveraging the insights gained from MIP technology, interfacial dynamics, and advanced encapsulation strategies, my work will focus on developing multi-functional biosensors capable of providing real-time feedback while addressing the challenges of sensitivity and reversibility. These sensors will be designed not only for accurate biomarker detection but also for adaptive responses to varying physiological conditions, thus facilitating personalized therapeutic interventions.

Seminar Organizer: Dr. Barak Hirshberg