Special Physical Chemistry Seminar: High-resolution solid-state NMR of macroscopically aligned samples: Pulse sequence development and sensitivity enhancement
Prof. Alexander Nevzorov, Department of Chemistry, North Carolina State University
Efficient dipolar decoupling and a uniform sample orientation are the most essential prerequisites for obtaining well-resolved peaks in solid-state NMR of membrane proteins aligned in planar, native-like lipid bilayers. We present a computer-assisted pulse sequence design method based on non-quadrature phases that provides up to 50% improvement in NMR linewidths observed in separated local field (SLF) experiments as compared to the classical SLF sequences derived using the Average Hamiltonian Theory. Moreover, we present a resonator approach to Dynamic Nuclear Polarization (DNP) in static samples employing photonic band-gap resonators which allows one to obtain up to 50-fold enhancement in the microwave powers concentrated at the sample for a more efficient DNP transfer.
Seminar Organizers: Prof. Haim Diamant