Biological & Soft Matter Seminar: Universal bounds on entropy production inferred from observed statistics

Eden Nitzan, TAU

15 March 2023, 11:00 
Kaplun Building, Flekser Hall 118 
Biological & Soft Matter Seminar



Nonequilibrium processes break time-reversal symmetry and generate entropy. Living systems are driven out-of-equilibrium at the microscopic level of molecular motors that exploit chemical potential gradients to transduce free energy to mechanical work, while dissipating energy. The amount of energy dissipation, or the entropy production rate (EPR),  sets thermodynamic constraints on cellular processes. Practically, calculating the total EPR in experimental systems is challenging due to the limited spatiotemporal resolution and the lack of complete information on every degree of freedom.


Here, we propose a new inference approach for a tight lower bound on the total EPR given partial information, based on an optimization scheme that uses the observed transitions and waiting times statistics. We introduce hierarchical bounds relying on the first- and second-order transitions, and the moments of the observed waiting time distributions, and apply our approach to two generic systems of a hidden network and a molecular motor, with lumped states. Finally, we show that a lower bound on the total EPR can be obtained even when assuming a simpler network topology of the full system.


Tel Aviv University makes every effort to respect copyright. If you own copyright to the content contained
here and / or the use of such content is in your opinion infringing, Contact us as soon as possible >>