Edmond J. Safra Center special seminar: "How cancers remain fit ? From population genetics to cancer therapy"

Speaker: Dr. Erez Persi

 Research Scientist, the National Institutes of Health (NIH), National Library of Medicine (NLM), National Center for Biotechnology Information (NCBI), Computational Biology Branch (CBB).

 

 

07 November 2021, 12:00 
Katzir seminar room, Green building, Life Sciences Faculty, TAU 
Edmond J. Safra Center special seminar: "How cancers remain fit ? From population genetics to cancer therapy"
You are cordially invited to a special seminar of the Edmond J. Safra Center for Bioinformatics
jointly with the Shmunis School of Biomedicine and Cancer Research
 
 
Dr. Erez Persi 
Research Scientist, the National Institutes of Health (NIH), National Library of Medicine (NLM),  National Center for Biotechnology Information (NCBI), Computational Biology Branch (CBB).
 
 
"How cancers remain fit ? From population genetics to cancer therapy"
 
 
Abstract: Cancer evolution is marked by genome instability, involving aberrations of all scales, from point mutations, somatic copy-number alterations, to whole genome duplications, under constantly changing environmental conditions. Although substantial progress has been made to understand the impact of each aberration alone on tumor fitness and patient survival, it remains incompletely understood how such aberrations jointly act to maintain cancers fitted throughout tumor progression. Using population genetics and systems biology approaches to analyze cancer data, I will provide evidence that the accumulation of aberrations has a temporal order, which is determined by a balance between the extent of an aberration and the selective pressures acting on it, with compensatory relationships among aberrations, leading to robust tumor fitness over time. Further, I will discuss how metabolic and epigenetic adaptations (phenotypic plasticity) to harsh environmental conditions in the tumor microenvironment (such as hypoxia, oxidative stress, and acidosis) might be linked to the mutagenesis of genomic aberrations, and how the complex relationship between phenotypic plasticity and genome evolution can expose cancer to vulnerabilities that may be exploited for therapeutics. Last, I will present new data of tumors evolved under stress, starting to unfold the co-evolution of cancer epi-genomes. 
 
 
 
Sunday 7 November 2021 at 12:15
 
In Katzir seminar room, Green building, Life Sciences Faculty, TAU
 
(Refreshments from 12:00)
 
 
Host:  Prof. Tal Pupko, the Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, TAU
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